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Research Projects

 

Ak Lamp 2022

 

The research in our group is focused on advanced drug delivery strategies for enhanced bioavailability of poorly absorbable drugs as well as selective drug delivery for a variety of pathologies. This includes formulation design not only for small molecules, but also peptides and proteins and their biopharmaceutical evaluation in-vitro and in-vivo in relevant cell culture or animal models. In order to permit a successful delivery a strong interest consists in the smart design of such drug delivery systems, among them micro- and nanoparticles, micro-emulsions, self-emulsifying systems, and liposomes. One further aspect are the related preparation techniques in view of a potential scale-up.

 

 Oral drug delivery 

  • Enhanced bioavailability of drugs
Oral delivery of poorly bioavailable drugs where low permeability is the main issue: reduction of impact of efflux systems as well as the design of new delivery systems for the oral delivery of pharmacologically active macromolecules

  • selective targeting to inflamed intestinal tissue
Drug targeting towards inflamed barriers at tissue as well as at cellular level, e.g. gastric ulcer or inflammatory bowel disease with a focus on understanding the adhesion and targeting mechanism in order to design an optimized drug delivery system.

 

 Drug delivery to the skin

  • Enhanced bioavailability of drugs
Enhanced drug delivery across the skin by the use of different transdermal patch approaches 

  • selective drug delivery to inflamed skin
Nanoscale drug delivery systems to provide an enhanced therapeutic effect locally and limited the transport of anti-inflammatory drugs across the skin

 

 Delivery to the lungs and nose

  • Enhanced bioavailability of drugs after nasal administration
Based on a spray freeze dried particle technology developed in the department the potential of nasal delivery of macromolecules is elucidated 

 

  •  Enhanced drug delivery into the deep lung
Particle engineering approaches based on spray drying and spray freeze drying techniques are tested for a more efficient lung deposition of drugs, including SME as well as protein drugs

 

 Drug delivery to the blood-brain-barrier


With the help of newly developed ex-vivo tissue model we aim for understanding drug transport mechanisms at the BBB and the related consequences for the design of efficient delivery strategies across the BBB

 

Immune therapy in cancer

 
A very recent project of our group is the design of nanoparticles as efficient and well-tolerated immunotherapeutics in cancer therapy

 

Controlled release of peptides and proteins


Design of biodegradable implants for sustained release of small molecules, peptides and proteins, including microspheres, monolithic implants as well as in-situ forming systems, biorelevant in-vitro test systems for the design of implants

 

 

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