One Two
Sie sind hier: Startseite → Research → Research Group Prof. Wagner → Publications

Publications

All publications can also be found on Prof. Wagner ORCID Page: https://orcid.org/0000-0003-2864-7191

 
Publications:
  • Dauer K., Wagner K. G., 2023, Micro-Scale Vacuum Compression Molding as a Predictive Screening Tool of Protein Integrity for Potential Hot-Melt Extrusion Processes, Pharmaceutics, https://doi.org/10.3390/pharmaceutics15030723
  • Kreiser M. J., Wabel C., Wagner K. G., 2023, Direct Tableting on a Continuous Manufacturing Line—Impact of Mixing Parameters, Material Densities, and Drug Load on Subsequent Process Parameters and Tablet Quality, AAPS PharmSciTech, https://doi.org/10.1208/s12249-023-02525-8
  • Pöstges F., Kayser K., Appelhaus J., Monschke M., Gütschow M., Steinebach C., Wagner K. G., 2023, Solubility Enhanced Formulation Approaches to Overcome Oral Delivery Obstacles of PROTACs, Pharmaceutics, https://doi.org/10.3390/pharmaceutics15010156
  • Dauer K., Werner C., Lindenblatt D., Wagner K. G., 2022,  Impact of process stress on protein stability in highly-loaded solid protein/PEG formulations from small-scale melt extrusion, International Journal of Pharmaceutics: X, 10.1016/j.ijpx.2022.100154
  • Becker T., Krome A. K., Vahdati S., Schiefer A., Pfarr K., Ehrenz A., Aden T., Grosse M., Jansen R., Alt S., Hesterkamp T., Stadler M., Hübner M. P., Hoerauf A., Wagner K. G., 2022, In Vitro-In Vivo Relationship in Mini-Scale--Enabeling Formulations of Corallopyrinin A, Pharmaceutics, https://doi.org/10.3390/pharmaceutics14081657
  • Willmann A-C., Berkenfeld K., Faber T., Wachtel H., Boeck G., Wagner K. G., 2022, Itraconazole Nanosuspensions via Dual Centrifugation Media Milling: Impact of Formulation and Process Parameters on Particle Size and Solid-State Conversion as Well as Storage Stability, Pharmaceutics, https://doi.org/10.3390/pharmaceutics14081528
  • Pöstges, F., Kayser, K., Stoyanov, E., Wagner, K.G., 2022. Boost of solubility and supersaturation of celecoxib via synergistic interactions of methacrylic acid-ethyl acrylate copolymer (1:1) and hydroxypropyl cellulose in ternary amorphous solid dispersions, International Journal of Pharmaceutics: X, 100115, 2022. https://doi.org/10.1016/j.ijpx.2022.100115
  • Barbara V. Schönfeld, Ulrich Westedt, Karl G. Wagner, 2022, Compression Modulus and Apparent Density of Polymeric Excipients during Compression—Impact on Tabletability, Pharmaceutics, https://doi.org/10.1208/s12249-021-02140-5 
  • Judith Menth, Martin Maus, Karl G. Wagner, 2022, Assessment of Abrasion-Induced Visual Defects in Twin Screw Wet Granulation Using Wall Friction Measurements , AAPS PharmScieTech, https://doi.org/10.1208/s12249-021-02140-5 
  • Lillotte T. D., Joester M., Fringdt B.,  Berghaus A., Lammes R. F., Wagner K. G., 2021. UV-VIS spectra as potential process analytical technology (PAT) for measureing the density of compressed materials: Evaluation of the CIELAB color space, International Journal of Pharmaceutics. https://doi.org/10.1016/j.ijpharm.2021.120668
  • Lopez Marmol A., Denninger A., Touzet A., Dauer K. , Becker T., Pöstges F., Pellequer Y., Lamprecht A.,  Wagner K. G., 2021. The Relevance of Supersaturation ans Solubilization in the Gastrointestinal Tract for oral Bioavailability: An In Vitro vs. In Vivo Approach, International Journal of Pharmaceutics.  https://doi.org/10.1016/j.ijpharm.2021.120648
  • Denninger A., Westedt U.,  Wagner K. G., 2021. Shared IVIVR for Five Commercial Enabling Formulations Using the BiPHa+ Biphasic Dissolution Assay, Pharmaceutics.  https://doi.org/10.3390/pharmaceutics13020285 
  • Dauer K.,  Kamm W., Wagner K. G., Pfeiffer-Marek S.,2021. High-Throuput Sceening for Colloidal Stability  of Peptide Formulations Using Dynamic and Static Light Scattering , Mol Pharm.  https://doi.org/10.1021/acs.molpharmaceut.0c01028
  • Dauer K.,  Pfeiffer-Marek S., Wagner K. G., 2021. Microwell Plate-Based Dynamic Light Scattering as a High-Throuput Characterization Tool in Biopharmaceutical Development, Pharmaceutics.  https://doi.org/10.3390/pharmaceutics13020172 
  • Bachmaier D, Monschke M., Faber T., Krome A. K. , Pellequer Y., Stoyanov, E., Lamprecht A., Karl G. Wagner, 2021, In vitro and in vivo assessment of hydroxypropyl cellulose as functional additive for enabling formulations containing itraconazole, International Journal of Pharmaceutics: X, 100076, 2021, https://doi.org/10.1016/j.ijpx.2021.100076
  • Steffens K. E., Brenner M. B., Hartig M. U., Monschke M., Wagner K. G., 2020. Melt granulation: A comparison of granules produced via high-shear mixing and twin-screw granulation, Int. Journal of Pharmaceutics. 591, 119941; 2020 https://doi.org/10.1016/j.ijpharm.2020.119941
  • Kapote D. N., Wagner K. G., 2020. Influence of shellac on the improvement of solubility and supersaturation of loratadine amorphous solid dispersion using a new grade of HPMC, Journal of Drug Delivery Science and Technology. 102116; 2020 https://doi.org/10.1016/j.jddst.2020.102116
  • Schiefer A., Hübner M.P., Krome A., Lämmer C., Ehrens A., Aden T., Koschel M., Neufeld H., Chaverra-Munoz L., Jansen R., Kehraus S., König G.M., Prgorevc D., Müller R., Stadler M., Hüttel S., Hesterkamp T., Wagner K.G., Kenneth Pfarr, Hoerauf A., 2020 Corallopyronin A for short-course anti-wolbachial, microfilaricidal treatment of filarial infections, Plos Neglegted Tropical Diseases, https://doi.org/10.1371/journal.pntd.008930 
  • Krome A., Becker T., Kehraus S., Schiefer A., Steinebach C., Aden T., Frohberger, S.J., Kapote D., Jansen R., Chaverra-Munoz L., Hübner M. P., Pfarr K., Hesterkamp T., Stadler M.,  Gütschow M., König G.M.,  Hörauf A., Wagner K.G., 2020 Solubility and Stability Enhanced Oral Formulations for the Anti-infective Corallopyronin A, Pharmaceutics, https://doi.org/10.3390/pharmaceutics12111105
  •  Steffens K. E., Wagner K. G., 2020. Compression behaviour of granules produced vis twin-scrw melt granulation: Effect of initial particle size on granulation efficiency, Powder Technology. 374; 2020 https://doi.org/10.1016/j.powtec.2020.07.037
  • Menth J., Maus M., Wagner K. G., 2020. Continious twin screw granulation and fluid bed drying: A mechanistic scaling approach focusing optimal tablet properties,  Int. Journal of Pharmaceutics. 586, 119509; 2020 https://doi.org/10.1016/j.ijpharm.2020.119509
  • Monschke M., Kayser K., Wagner*, K.G., 2019. Impact of HPMCAS on the Dissolution Performance of Polyvinyl Alcohol Celecoxib Amorphous Solid Dispersions, Pharmaceutics. 12(6), 541. https://doi.org/10.3390/pharmaceutics1206054 
  • Monschke M., Kayser K., Wagner*, K.G., 2019. Processing of Polyvinyl Acetate Phthalate in Hot-Melt-Extrusion - Preparation of Amorphous Solid Dispersions, Pharmaceutics. 12(4), 337.  https://doi.org/10.3390/pharmaceutics12040337
  • Denninger A., Weststedt U., Rosenberg J., Wagner K. G., 2020. A Rational Design of a Biphasic Dissolution Setup - Modelling of Biorelevant Kinetics for a Ritonavir Hot-Melt Extruded Amorphous Solid Dispersion, Pharmaceutics. 2020, 12(3), 237 https://doi.org/10.1016/j.ijpharm.2020.119941
  • Steffens K. E., Wagner K. G., 2020., Dissolution enhancement of carbamazepine using twin-srew melt granulation, European Journal of Pharmaceutics and Biopharmaceutics. 148, 2020 https://doi.org/10.1016/j.ejpb.2020.01.006
  • Hagelstein V., Frindt B., Hucke M., Pieper J., Carstens J., Lammens R. F., Wagner K. G., 2019., Novel ultrasonic in-die measurements during power compression at production relevant speed, Int. Journal of Pharmaceutics. 571, 118761; 2019 https://doi.org/10.1016/j.ijpharm.2019.118761
  • Steffens K. E., Wagner K. G. , Improvement of tablet ability via twin-screw melt granulation: Focus on bindeer distribution, Int. Journal of Pharmaceutics. 570, 118649; 2019 https://doi.org/10.1016/j.ijpharm.2019.118649 
  • Steinebach C., Sonic I., Lindner S., Bricelj A., Kohl F., Ng Y.L.D., Monschke M., Wagner K.G., Krönke J., Gütchow*, M., 2019. A MedChem toolbox for cereblon-directed PROTACs, MedChemComm, doi:10.1039/C9MD00185A
  • Evans C.E., Bochmann E.S., Kyeremateng S.O., Grycczke A., Wagner*, K.G., 2019., Holistic QbD approuch for hot-melt extrusion process design space evaluation: Linking materials science, experimentation and process modeling, Eur. J. Pharm. Biopharm. 141, 149–160. doi:10.1016/j.ejb.2019.05.021
  • Bochmann, E.S., Neumann, D., Gryczke, A., Wagner*, K.G., 2019. Micro-scale solubility assessments and prediction models for active pharmaceutical ingredients in polymeric matrices, Eur. J. Pharm. Biopharm. 141, 111–120. doi:10.1016/j.ejpb.2019.05.012
  • Monschke M., Wagner*, K.G., 2019. Amorphous solid dispersions of weak bases with pH-dependent soluble polymers to overcome limited bioavailability due to gastric pH variability - An in vitro approach, Int. Journal of Pharmaceutics. 564, 162-170. doi:10.1016/j.ipharm.2019.04.034
  • Simons J.F., Wagner*, K.G., 2019., Modeling, design and manufacture of innovative floating gastroretentive drug delivery systems based on hot-melt extrusion., Eur. J. Pharm. Biopharm. 137, 196-208. doi:10.1016/j.ejpb.2019.02.022
  • Steinebach C., Kehm H., Lindner S., Vu L.P., Köpff S., Lopez Marmol A., Weiler C., Wagner K.G., Reichenzeller M., Krönke J., Gütschow*,M. 2019. PROTAC-mediated crosstalk between E3 ligases. Chemical Communications. 55, 1821-1824. doi:10.1039/C8CC09541H
  • Evans C.E., Kyeremateng S.O.,  Asmus L., Degenhardt M., Rosenberg J., Wagner*, K.G., 2019. Development and Performance of Highly Sensitive Model Formulation Based on Torasemide to Enhance Hot-Melt Extrusion Process Understanding and Process Development, AAPS PharmSciTech. 19, 1592-1605. doi:10.1208/s1224.9-018-0970-y
  • Zecevic D.E., Evans C.E., Paulsen K., Wagner*, K.G., 2019., From benchtop to pilot scale-experimental study and computational assessment of a hot-melt extrusion scale up of a solid dispersion od dipyridamole and copovidone, Int. Journal of Pharmaceutics. 537, 132-139. doi:10.1016/j.ijpharm.2017.12.033
  • Locher K., Borghaedt J.M., Wachtel H., Schaefer K.J., Wagner*, K.G., 2018. Mechanistic study on hydrodynamics in the mini-scale biphasic dissolution model and its influence on in vitro dissolution and partitioning, Eur. J. Pharm. Biopharm. 124, 328-338. doi:10.1016/j.ejpb.2018.09.005
  • Bochmann, E.S., Steffens K.E., Gryczke, A., Wagner*, K.G., 2017. Numerical simulation of hot-melt extrusion processes for amorphous solid dispersions using model-based melt viscosity, Eur. J. Pharm. Biopharm. 124, 34-42. doi:10.1016/j.ejpb.20176.12.001
  • Hagelstein V., Gerhart M. and Wagner*, K.G., 2018. Tricalcium citrate -  a new brittle tableting excipient for direct compression and drygranulation with enormous hardness yield Drug Development and Industrial Pharmacy. doi:10.1080/03639045.2018.1483389
  • Bochmann, E.S., Neumann, D., Gryczke, A., Wagner*, K.G., 2016. Validation of Model-Based Melt Viscosity in Hot-Melt Extrusion Numerical Simulation, Pharmaceutics. 10(3), 132. doi:10.3390/pharmaceutics10030132
  • Cossé, A., König, C., Lamprecht, A., Wagner*, K.G., 2017. Hot Melt Extrusion for Sustained Protein Release: Matrix Erosion and In Vitro Release of PLGA-Based Implants. AAPS PharmSciTech 1–12. doi:10.1208/s12249-016-0548-5
  • Bochmann, E.S., Üstüner E.E., Gryczke, A., Wagner*, K.G., 2017. Predicting melt rheology for hot-melt extrusion by means of simple Tg-measurent Eur. J. Pharm. Biopharm. 119, 47-55. doi:10.1016/j.ejpb.2017.05.010
  • Schmidtke R., Schröder D., Menth J., Staab A., Braun M., Wagner*, K.G., 2017. Prediction of solid fraction from powder mixtures based on single component compression analysis, Int. Journal of Pharmaceutics. 523, 366.375. doi:10.1016/j.ijpharm.2017.03.054
  • Locher, K., Borghardt, J.M., Frank, K.J., Kloft, C., Wagner*, K.G., 2016. Evolution of a mini-scale biphasic dissolution model: Impact of model parameters on partitioning of dissolved API and modelling of in vivo-relevant kinetics. Eur. J. Pharm. Biopharm. 105, 166–175. doi:10.1016/j.ejpb.2016.06.008
  • Gierds J., Wagner*, K.G., 2016.mHPAPIs in tableting: Perspectives for the effect and processing of highly potent active pharmaceutical ingredients, Pharmazeutische Industrie, Vol 78, issue 8, 2016, 1215-11221
  • Bochmann, E.S., Neumann, D., Gryczke, A., Wagner*, K.G., 2016. Micro-scale prediction method for API-solubility in polymeric matrices and process model for forming amorphous solid dispersion by hot-melt extrusion. Eur. J. Pharm. Biopharm. 107, 40–48. doi:10.1016/j.ejpb.2016.06.015
  • Wagner, K.G., 2016. Perorale Retardarzneiformen PHARMAKON 4, 107–116. doi:10.1691/pn.20160013
  • Zecevic, D.E., Meier, R., Daniels, R., Wagner*, K.-G., 2014. Site specific solubility improvement using solid dispersions of HPMC-AS/HPC SSL - Mixtures. Eur. J. Pharm. Biopharm. 87, 264–270. doi:10.1016/j.ejpb.2014.03.018
  • Frank, K.J., Locher, K., Zecevic, D.E., Fleth, J., Wagner*, K.G., 2014. In vivo predictive mini-scale dissolution for weak bases: Advantages of pH-shift in combination with an absorptive compartment. Eur. J. Pharm. Sci. 61, 32–39. doi:10.1016/j.ejps.2013.12.015
  • Zecevic, D.E., Wagner*, K.G., 2013. Rational development of solid dispersions via hot-melt extrusion using screening, material characterization, and numeric simulation tools. J. Pharm. Sci. 102, 2297–2310. doi:10.1002/jps.23592
  • Buske, J., König, C., Bassarab, S., Lamprecht, A., Mühlau, S., Wagner*, K.G., 2012. Influence of PEG in PEG-PLGA microspheres on particle properties and protein release. Eur. J. Pharm. Biopharm. doi:10.1016/j.ejpb.2012.01.009
  • Heigoldt, U., Sommer, F., Daniels, R., Wagner*, K.-G., 2010. Predicting in vivo absorption behavior of oral modified release dosage forms containing pH-dependent poorly soluble drugs using a novel pH-adjusted biphasic in vitro dissolution test. Eur. J. Pharm. Biopharm. 76, 105–111. doi:10.1016/j.ejpb.2010.05.006 
  • Maus, M., Wagner, K.G., Kornherr, A., Zifferer*, G., 2008. Molecular dynamics simulations for drug dosage form development: thermal and solubility characteristics for hot-melt extrusion. Mol. Simul. 34, 1197–1207. doi:10.1080/08927020802411695
  • Günther, M., Maus, M., Wagner, K.G., Schmidt*, P.C., 2005. Hydrophilic solutes in modified carbon dioxide extraction—prediction of the extractability using molecular dynamic simulation. Eur. J. Pharm. Sci. 25, 321–329. doi:10.1016/j.ejps.2005.03.007
  • Wagner, K.G., Maus, M., Kornherr*, A., Zifferer, G., 2005. Glass transition temperature of a cationic polymethacrylate dependent on the plasticizer content – Simulation vs. experiment. Chem. Phys. Lett. 406, 90–94. doi:10.1016/j.cplett.2005.02.095
  • Gruetzmann, R., Wagner*, K.G., 2005. Quantification of the leaching of triethyl citrate/polysorbate 80 mixtures from Eudragit® RS films by differential scanning calorimetry. Eur. J. Pharm. Biopharm. 60, 159–162. doi:10.1016/j.ejpb.2004.11.004
  • Wagner*, K.G., Gruetzmann, R., 2005. Anion-induced water flux as drug release mechanism through cationic Eudragit RS 30D film coatings. AAPS J. 7, E668–E677. doi:10.1208/aapsj070367
  • Wagner*, K.G., Dowe, U., Zadnik, J., 2005. Highly loaded interactive mixtures for dry powder inhalers: Prediction of the adhesion capacity using surface energy and solubility parameters. Pharm. - Int. J. Pharm. Sci. 60, 339–344.
  • Jonat, S., Hasenzahl, S., Drechsler, M., Albers, P., Wagner, K.G., Schmidt*, P.C., 2004. Investigation of compacted hydrophilic and hydrophobic colloidal silicon dioxides as glidants for pharmaceutical excipients. Powder Technol. 141, 31–43. doi:10.1016/j.powtec.2004.01.020
  • Wagner*, K.G., Dressler, J.A., 2003. A corn starch/α-lactose monohydrate compound as a directly compressible excipient. Pharm. Technol. Eur. 15, 33–40.
  • Wagner*, K.G., McGinity, J.W., 2002. Influence of chloride ion exchange on the permeability and drug release of Eudragit RS 30 D films. J. Controlled Release 82, 385–397. doi:10.1016/S0168-3659(02)00145-1
  • Dressler, J.A., Wagner, K.G., Wahl, M.A., Schmidt*, P.C., 2001. Comparison of incremental and inductive displacement transducers on an eccentric tablet press. Drugs Made Ger. 44, 70–77.
  • Rey, H., Wagner, K.G., Wehrle, P., Schmidt*, P.C., 2000. Development of matrix-based theophylline sustained-release microtablets. Drug Dev. Ind. Pharm. 26, 21–26. doi:10.1081/DDC-100100323
  • Wagner, K.G., Krumme, M., Beckert, T.E., Schmidt*, P.C., 2000. Development of disintegrating multiple-unit tablets on a high-speed rotary tablet press. Eur. J. Pharm. Biopharm. 50, 285–292. doi:10.1016/S0939-6411(00)00078-3
  • Wagner, K.G., Krumme, M., Schmidt*, P.C., 2000. Pellet-containing tablets - Examination of distribution and deformation behaviour. STP Pharma Sci. 10, 327–334.
  • Wagner, K.G., Krumme, M., Schmidt*, P.C., 1999. Investigation of the pellet-distribution in single tablets via image analysis. Eur. J. Pharm. Biopharm. 47, 79–85. doi:10.1016/S0939-6411(98)00090-3

 

Patents:

 

  • Wagner, K., Boeck, G., Radtke, G., 2014.

Immediate Release Multi Unit Pellet System.

EP2793864 (A1) Abstract of corresponding document: WO2013092497 (A1).

 

  • Brickl, R.-S., Boni, J., Wagner, K.G., 2009.

Formulations of Flibanserin.

WO2009100886 (A2).

 

  • Eisenreich, W., Friedl, T., Sommer, F., Pearnchob, N., Wagner, K.G., 2008.

Extended release tablet formulations of flibanserin and method for manufacturing the same. US2008038347 (A1); US8658207 (B2).

 

  • Pearnchob, N., Friedl, T., Wagner, K.G., Sommer, F., Wagner, K.G., 2008.

Controlled release system and method for manufacturing the same.

US2008069873 (A1).

 

Book Chapter:

 

  • Maus, M., Wagner, K.G., Kornherr, A., Zifferer, G., 2011. Molecular dynamics simulation for drug dosage form development: thermal and solubility characteristics for hot-melt extrusion, in: Meunier, M. (Ed.), Industrial Applications of Molecular Simulations. CRC Press, pp. 241–260.

 


* corresponding author 

Artikelaktionen