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Publications

All publications can also be found on Prof. Wagner ORCID Page: https://orcid.org/0000-0003-2864-7191

 
Publications:
 
  • Hagelstein V., Frindt B., Hucke M., Pieper J., Carstens J., Lammens R. F., Wagner K. G., 2019.
Novel ultrasonic in-die measurements during power compression at production relevant speed

Int. Journal of Pharmaceutics. 571, 118761; 2019 https://doi.org/10.1016/j.ijpharm.2019.118761

  • Steffens K. E., Wagner K. G. 
Improvement of tablet ability via twin-screw melt granulation: Focus on binder distribution

Int. Journal of Pharmaceutics. 570, 118649; 2019 https://doi.org/10.1016/j.ijpharm.2019.118649

     

  • Steinebach C., Sonic I., Lindner S., Bricelj A., Kohl F., Ng Y.L.D., Monschke M., Wagner K.G., Krönke J., Gütchow*, M., 2019.

A MedChem toolbox for cereblon-directed PROTACs

MedChemComm, doi:10.1039/C9MD00185A

 

  • Evans C.E., Bochmann E.S., Kyeremateng S.O., Grycczke A., Wagner*, K.G., 2019.

Holistic QbD approuch for hot-melt extrusion process design space evaluation: Linking materials science, experimentation and process modeling

Eur. J. Pharm. Biopharm. 141, 149–160. doi:10.1016/j.ejb.2019.05.021

 
  • Bochmann, E.S., Neumann, D., Gryczke, A., Wagner*, K.G., 2019.

Micro-scale solubility assessments and prediction models for active pharmaceutical ingredients in polymeric matrices

Eur. J. Pharm. Biopharm. 141, 111–120. doi:10.1016/j.ejpb.2019.05.012

 
  • Monschke M., Wagner*, K.G., 2019.

Amorphous solid dispersions of weak bases with pH-dependent soluble polymers to overcome limited bioavailability due to gastric pH variability - An in vitro approach

Int. Journal of Pharmaceutics. 564, 162-170. doi:10.1016/j.ipharm.2019.04.034


  • Simons J.F., Wagner*, K.G., 2019.

Modeling, design and manufacture of innovative floating gastroretentive drug delivery systems based on hot-melt extrusion.

Eur. J. Pharm. Biopharm. 137, 196-208. doi:10.1016/j.ejpb.2019.02.022

 
  • Steinebach C., Kehm H., Lindner S., Vu L.P., Köpff S., Lopez Marmol A., Weiler C., Wagner K.G., Reichenzeller M., Krönke J., Gütschow*,M. 2019.

PROTAC-mediated crosstalk between E3 ligases.

Chemical Communications. 55, 1821-1824. doi:10.1039/C8CC09541H

 

  • Evans C.E., Kyeremateng S.O.,  Asmus L., Degenhardt M., Rosenberg J., Wagner*, K.G., 2019.

Development and Performance of Highly Sensitive Model Formulation Based on Torasemide to Enhance Hot-Melt Extrusion Process Understanding and Process Development

AAPS PharmSciTech. 19, 1592-1605. doi:10.1208/s1224.9-018-0970-y

 

  • Zecevic D.E., Evans C.E., Paulsen K., Wagner*, K.G., 2019.

From benchtop to pilot scale-experimental study and computational assessment of a hot-melt extrusion scale up of a solid dispersion od dipyridamole and copovidone

 Int. Journal of Pharmaceutics. 537, 132-139. doi:10.1016/j.ijpharm.2017.12.033

 

  • Locher K., Borghaedt J.M., Wachtel H., Schaefer K.J., Wagner*, K.G., 2018.

Mechanistic study on hydrodynamics in the mini-scale biphasic dissolution model and its influence on in vitro dissolution and partitioning

Eur. J. Pharm. Biopharm. 124, 328-338. doi:10.1016/j.ejpb.2018.09.005

 

  • Bochmann, E.S., Steffens K.E., Gryczke, A., Wagner*, K.G., 2017.

Numerical simulation of hot-melt extrusion processes for amorphous solid dispersions using model-based melt viscosity

Eur. J. Pharm. Biopharm. 124, 34-42. doi:10.1016/j.ejpb.20176.12.001

 

  • Hagelstein V., Gerhart M. and Wagner*, K.G., 2018.

Tricalcium citrate -  a new brittle tableting excipient for direct compression and drygranulation with enormous hardness yield

Drug Development and Industrial Pharmacy. doi:10.1080/03639045.2018.1483389

 

  • Bochmann, E.S., Neumann, D., Gryczke, A., Wagner*, K.G., 2016.

Validation of Model-Based Melt Viscosity in Hot-Melt Extrusion Numerical Simulation

Pharmaceutics. 10(3), 132. doi:10.3390/pharmaceutics10030132

 

  • Cossé, A., König, C., Lamprecht, A., Wagner*, K.G., 2017.

Hot Melt Extrusion for Sustained Protein Release: Matrix Erosion and In Vitro Release of PLGA-Based Implants.

AAPS PharmSciTech 1–12. doi:10.1208/s12249-016-0548-5

 

  • Bochmann, E.S., Üstüner E.E., Gryczke, A., Wagner*, K.G., 2017.

Predicting melt rheology for hot-melt extrusion by means of simple Tg-measurent

Eur. J. Pharm. Biopharm. 119, 47-55. doi:10.1016/j.ejpb.2017.05.010

 

  • Schmidtke R., Schröder D., Menth J., Staab A., Braun M., Wagner*, K.G., 2017.

Prediction of solid fraction from powder mixtures based on single component compression analysis

 Int. Journal of Pharmaceutics. 523, 366.375. doi:10.1016/j.ijpharm.2017.03.054

 

  • Locher, K., Borghardt, J.M., Frank, K.J., Kloft, C., Wagner*, K.G., 2016.

Evolution of a mini-scale biphasic dissolution model: Impact of model parameters on partitioning of dissolved API and modelling of in vivo-relevant kinetics.

Eur. J. Pharm. Biopharm. 105, 166–175. doi:10.1016/j.ejpb.2016.06.008

 

  • Gierds J., Wagner*, K.G., 2016.

HPAPIs in tableting: Perspectives for the effect and processing of highly potent active pharmaceutical ingredients

Pharmazeutische Industrie, Vol 78, issue 8, 2016, 1215-11221


  • Bochmann, E.S., Neumann, D., Gryczke, A., Wagner*, K.G., 2016.

Micro-scale prediction method for API-solubility in polymeric matrices and process model for forming amorphous solid dispersion by hot-melt extrusion.

Eur. J. Pharm. Biopharm. 107, 40–48. doi:10.1016/j.ejpb.2016.06.015

 

  • Wagner, K.G., 2016.

Perorale Retardarzneiformen

PHARMAKON 4, 107–116. doi:10.1691/pn.20160013

 

  • Zecevic, D.E., Meier, R., Daniels, R., Wagner*, K.-G., 2014.

Site specific solubility improvement using solid dispersions of HPMC-AS/HPC SSL - Mixtures.

Eur. J. Pharm. Biopharm. 87, 264–270. doi:10.1016/j.ejpb.2014.03.018

 

  • Frank, K.J., Locher, K., Zecevic, D.E., Fleth, J., Wagner*, K.G., 2014.

In vivo predictive mini-scale dissolution for weak bases: Advantages of pH-shift in combination with an absorptive compartment.

Eur. J. Pharm. Sci. 61, 32–39. doi:10.1016/j.ejps.2013.12.015

 

  • Zecevic, D.E., Wagner*, K.G., 2013.

Rational development of solid dispersions via hot-melt extrusion using screening, material characterization, and numeric simulation tools.

J. Pharm. Sci. 102, 2297–2310. doi:10.1002/jps.23592

 

  • Buske, J., König, C., Bassarab, S., Lamprecht, A., Mühlau, S., Wagner*, K.G., 2012.

Influence of PEG in PEG-PLGA microspheres on particle properties and protein release.

Eur. J. Pharm. Biopharm. doi:10.1016/j.ejpb.2012.01.009

 

  • Heigoldt, U., Sommer, F., Daniels, R., Wagner*, K.-G., 2010.

Predicting in vivo absorption behavior of oral modified release dosage forms containing pH-dependent poorly soluble drugs using a novel pH-adjusted biphasic in vitro dissolution test.

Eur. J. Pharm. Biopharm. 76, 105–111. doi:10.1016/j.ejpb.2010.05.006

 

  • Maus, M., Wagner, K.G., Kornherr, A., Zifferer*, G., 2008.

Molecular dynamics simulations for drug dosage form development: thermal and solubility characteristics for hot-melt extrusion.

Mol. Simul. 34, 1197–1207. doi:10.1080/08927020802411695

 

  • Günther, M., Maus, M., Wagner, K.G., Schmidt*, P.C., 2005.

Hydrophilic solutes in modified carbon dioxide extraction—prediction of the extractability using molecular dynamic simulation.

Eur. J. Pharm. Sci. 25, 321–329. doi:10.1016/j.ejps.2005.03.007

 

  • Wagner, K.G., Maus, M., Kornherr*, A., Zifferer, G., 2005.

Glass transition temperature of a cationic polymethacrylate dependent on the plasticizer content – Simulation vs. experiment.

Chem. Phys. Lett. 406, 90–94. doi:10.1016/j.cplett.2005.02.095

 

  • Gruetzmann, R., Wagner*, K.G., 2005.

Quantification of the leaching of triethyl citrate/polysorbate 80 mixtures from Eudragit® RS films by differential scanning calorimetry.

Eur. J. Pharm. Biopharm. 60, 159–162. doi:10.1016/j.ejpb.2004.11.004

 

  • Wagner*, K.G., Gruetzmann, R., 2005.

Anion-induced water flux as drug release mechanism through cationic Eudragit RS 30D film coatings.

AAPS J. 7, E668–E677. doi:10.1208/aapsj070367

 

  • Wagner*, K.G., Dowe, U., Zadnik, J., 2005.

Highly loaded interactive mixtures for dry powder inhalers: Prediction of the adhesion capacity using surface energy and solubility parameters.

Pharm. - Int. J. Pharm. Sci. 60, 339–344.

 

  • Jonat, S., Hasenzahl, S., Drechsler, M., Albers, P., Wagner, K.G., Schmidt*, P.C., 2004.

Investigation of compacted hydrophilic and hydrophobic colloidal silicon dioxides as glidants for pharmaceutical excipients.

Powder Technol. 141, 31–43. doi:10.1016/j.powtec.2004.01.020

 

  • Wagner*, K.G., Dressler, J.A., 2003.

A corn starch/α-lactose monohydrate compound as a directly compressible excipient.

Pharm. Technol. Eur. 15, 33–40.

 

  • Wagner*, K.G., McGinity, J.W., 2002.

Influence of chloride ion exchange on the permeability and drug release of Eudragit RS 30 D films.

J. Controlled Release 82, 385–397. doi:10.1016/S0168-3659(02)00145-1

 

  • Dressler, J.A., Wagner, K.G., Wahl, M.A., Schmidt*, P.C., 2001.

Comparison of incremental and inductive displacement transducers on an eccentric tablet press. Drugs Made Ger. 44, 70–77.

 

  • Rey, H., Wagner, K.G., Wehrle, P., Schmidt*, P.C., 2000.

Development of matrix-based theophylline sustained-release microtablets.

Drug Dev. Ind. Pharm. 26, 21–26. doi:10.1081/DDC-100100323

 

  • Wagner, K.G., Krumme, M., Beckert, T.E., Schmidt*, P.C., 2000.

Development of disintegrating multiple-unit tablets on a high-speed rotary tablet press.

Eur. J. Pharm. Biopharm. 50, 285–292. doi:10.1016/S0939-6411(00)00078-3

 

  • Wagner, K.G., Krumme, M., Schmidt*, P.C., 2000.

Pellet-containing tablets - Examination of distribution and deformation behaviour.

STP Pharma Sci. 10, 327–334.

 

  • Wagner, K.G., Krumme, M., Schmidt*, P.C., 1999.

Investigation of the pellet-distribution in single tablets via image analysis.

Eur. J. Pharm. Biopharm. 47, 79–85. doi:10.1016/S0939-6411(98)00090-3

 

Patents:

 

  • Wagner, K., Boeck, G., Radtke, G., 2014.

Immediate Release Multi Unit Pellet System.

EP2793864 (A1) Abstract of corresponding document: WO2013092497 (A1).

 

  • Brickl, R.-S., Boni, J., Wagner, K.G., 2009.

Formulations of Flibanserin.

WO2009100886 (A2).

 

  • Eisenreich, W., Friedl, T., Sommer, F., Pearnchob, N., Wagner, K.G., 2008.

Extended release tablet formulations of flibanserin and method for manufacturing the same. US2008038347 (A1); US8658207 (B2).

 

  • Pearnchob, N., Friedl, T., Wagner, K.G., Sommer, F., Wagner, K.G., 2008.

Controlled release system and method for manufacturing the same.

US2008069873 (A1).

 

Book Chapter:

 

  • Maus, M., Wagner, K.G., Kornherr, A., Zifferer, G., 2011. Molecular dynamics simulation for drug dosage form development: thermal and solubility characteristics for hot-melt extrusion, in: Meunier, M. (Ed.), Industrial Applications of Molecular Simulations. CRC Press, pp. 241–260.

 



* corresponding author 

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